The Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Lung Architecture Remodeling

Antioxidants

Viswanathan Natarajan¹  Anantha Harijith²  Panfeng Fu³ 

[1] Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA;Department of Pediatric, University of Illinois at Chicago, Chicago, IL 60612, USA;Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA;

关键词: NADPH oxidase;    remodeling;    PAH;    COPD;    asthma;    BPD;   

DOI  :  10.3390/antiox6040104

来源: DOAJ

【 摘 要 】

Chronic lung disorders, such as pulmonary artery hypertension (PAH), chronic obstructive pulmonary disease (COPD), asthma and neonatal bronchopulmonary dysplasia (BPD), are characterized by airway and/or vascular remodeling. Despite differences in the pathology, reactive oxygen species (ROS) have been highlighted as a critical contributor to the initiation and development of airway and vascular remodeling. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) appear to play a pivotal role in lung signaling, leading to marked changes in pulmonary airway and vascular cell phenotypes, including proliferation, hypertrophy and apoptosis. In this review, we summarized the current literature regarding the role of Nox in the airway and vascular remodeling.

【 授权许可】

Unknown