Generation and function of induced regulatory T cells

Frontiers in Immunology

Erica G Schmitt¹  Calvin B Williams¹ 

[1] Medical College of Wisconsin;

关键词: Gene Expression Profiling;    Immunotherapy;    TCR repertoire;    Treg cells;    Treg stability;    Treg function;   

DOI  :  10.3389/fimmu.2013.00152

来源: DOAJ

【 摘 要 】

CD4+ CD25+ Foxp3+ regulatory T (Treg) cells are essential to the balance between pro- and anti-inflammatory responses.There are two major subsets of Treg cells, natural Treg (nTreg) cells that develop in the thymus, and induced Treg (iTreg) cells that arise in the periphery from CD4+ Foxp3– conventional T (Tconv) cells and can be generated in vitro.Previous work has established that both subsets are required for immunological tolerance.Additionally, in vitro-derived iTreg cells can reestablish tolerance in situations where Treg cells are decreased or defective.This review will focus on iTreg cells, drawing comparisons to nTreg cells when possible.We discuss the molecular mechanisms of iTreg cell induction, both in vivo and in vitro, review the Foxp3-dependent and -independent transcriptional landscape of iTreg cells, and examine the proposed suppressive mechanisms utilized by each Treg cell subset.We also compare the T cell receptor repertoire of the Treg cell subsets, discuss inflammatory conditions where iTreg cells are generated or have been used for treatment, and address the issue of iTreg cell stability.

【 授权许可】

Unknown