Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration

Bioactive Materials

Daniel Rothamel¹  Akiva Elad¹  Patrick Rider²  Gerrit Sauer³  Fabien Bornert³  Dávid Botond Hangyási⁴  Peter Windisch⁴  Balint Molnar⁵  Željka Perić Kačarević⁶  Till Kämmerer⁷  Emely Bortel⁷  Bernhard Hesse⁷  Drazen Tadic⁸  Marco Bartosch⁹  Frank Witte^1,10 

[1] Botiss Biomaterials AG, Ullsteinstrasse 108, 12109, Berlin, Germany;Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité – Universitätsmedizin Berlin, Aßmannshauser Straße 4–6, 14197, Berlin, Germany;Botiss Biomaterials AG, Ullsteinstrasse 108, 12109, Berlin, Germany;CMF Surgery, Johannes BLA Hospital, Mönchengladbach, Germany;Dental Clinic, University of Strasbourg, France;Department of Anatomy Histology, Embryology, Pathology Anatomy and Pathology Histology, Faculty of Dental Medicine and Health, University of Osijek, Osijek, 31000, Croatia;Department of Periodontology, Semmelweis University, Budapest, Hungary;Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité – Universitätsmedizin Berlin, Aßmannshauser Straße 4–6, 14197, Berlin, Germany;University Hospital Munich, Department of Dermatology and Allergy, Frauenlobstr. 9-11, 80337, Munich, Germany;Xploraytion GmbH, Bismarkstrasse 11, Berlin, Germany;

关键词: Magnesium;    Biodegradable;    Implant;    GBR;    Bone healing;    Soft tissue healing;   

DOI  :  

来源: DOAJ

【 摘 要 】

An ideal fixation system for guided bone (GBR) regeneration in oral surgery must fulfil several criteria that includes the provision of adequate mechanical fixation, complete resorption when no longer needed, complete replacement by bone, as well as be biocompatible and have a good clinical manageability. For the first time, a biodegradable magnesium fixation screw made of the magnesium alloy WZM211 with a MgF2 coating has been designed and tested to fulfill these criteria. Adequate mechanical fixation was shown for the magnesium fixation screw in several benchtop tests that directly compared the magnesium fixation screw with an equivalent polymeric resorbable device. Results demonstrated slightly superior mechanical properties of the magnesium device in comparison to the polymeric device even after 4 weeks of degradation. Biocompatibility of the magnesium fixation screw was demonstrated in several in vitro and in vivo tests. Degradation of the magnesium screw was investigated in in vitro and in vivo tests, where it was found that the screw is resorbed slowly and completely after 52 weeks, providing adequate fixation in the early critical healing phase. Overall, the magnesium fixation screw demonstrates all of the key properties required for an ideal fixation screw of membranes used in guided bone regeneration (GBR) surgeries.

【 授权许可】

Unknown