Synonymous mutations that regulate translation speed might play a non-negligible role in liver cancer development

BMC Cancer

Shuai Chang¹  Song Wang¹  Jian Li¹  Qun Li¹  Ling-ling Xie¹  Chun-peng Yu¹ 

[1] Department of interventional radiology, The Affiliated Hospital of Qingdao University;

关键词: Liver cancer;    Synonymous mutations;    Codon usage;    Gene expression;    Translation;   

DOI  :  10.1186/s12885-021-08131-w

来源: DOAJ

【 摘 要 】

Abstract Background Synonymous mutations do not change the protein sequences. Automatically, they have been regarded as neutral events and are ignored in the mutation-based cancer studies. However, synonymous mutations will change the codon optimality, resulting in altered translational velocity. Methods We fully utilized the transcriptome and translatome of liver cancer and normal tissue from ten patients. We profiled the mutation spectrum and examined the effect of synonymous mutations on translational velocity. Results Synonymous mutations that increase the codon optimality significantly enhanced the translational velocity, and were enriched in oncogenes. Meanwhile, synonymous mutations decreasing codon optimality slowed down translation, and were enriched in tumor suppressor genes. These synonymous mutations significantly contributed to the translational changes in tumor samples compared to normal samples. Conclusions Synonymous mutations might play a role in liver cancer development by altering codon optimality and translational velocity. Synonymous mutations should no longer be ignored in the genome-wide studies.

【 授权许可】

Unknown