OMICS Applications for Medicinal Plants in Gastrointestinal Cancers: Current Advancements and Future Perspectives

Frontiers in Pharmacology

Rongchen Dai¹  Yang Li¹  Zhichao Xi¹  Mengfan Liu¹  Xincheng Xiang¹  Hongxi Xu³ 

[1] Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, China;School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China;Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;

关键词: gastrointestinal cancers;    omics;    medicinal plants;    multi-omics;    precision medicine;    tumour heterogeneity;   

DOI  :  10.3389/fphar.2022.842203

来源: DOAJ

【 摘 要 】

Gastrointestinal cancers refer to a group of deadly malignancies of the gastrointestinal tract and organs of the digestive system. Over the past decades, considerable amounts of medicinal plants have exhibited potent anticancer effects on different types of gastrointestinal cancers. OMICS, systems biology approaches covering genomics, transcriptomics, proteomics and metabolomics, are broadly applied to comprehensively reflect the molecular profiles in mechanistic studies of medicinal plants. Single- and multi-OMICS approaches facilitate the unravelling of signalling interaction networks and key molecular targets of medicinal plants with anti-gastrointestinal cancer potential. Hence, this review summarizes the applications of various OMICS and advanced bioinformatics approaches in examining therapeutic targets, signalling pathways, and the tumour microenvironment in response to anticancer medicinal plants. Advances and prospects in this field are also discussed.

【 授权许可】

Unknown