Laryngotracheobronchial amyloidosis: A case report

Respiratory Medicine Case Reports

Le Tu Phuong Thuy¹  Thieu-Thi Tra My²  Nguyen Ba Tung³  Le Thuong Vu⁴  Pham Minh Thong⁵  Nguyen Minh Duc⁵ 

[1] Corresponding author. Department of Radiology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam.;Department of Radiology, Children's Hospital 2, Ho Chi Minh City, Viet Nam;Department of Radiology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam;Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam;Department of Radiology, Ha Noi Medical University, Ha Noi, Viet Nam;

关键词: Amyloidosis;    Congo red;    Laryngotracheobronchial;    Pulmonary;   

DOI  :  

来源: DOAJ

【 摘 要 】

Primary laryngotracheobronchial amyloidosis is a rare pulmonary disease that can cause endobronchial stenosis. This disease has never previously been reported in Vietnam. We aimed to report a laryngotracheobronchial amyloidosis case in a 43-year-old female, which may be the first reported case in Vietnam. The patient had a 4-year history of progressive hoarseness, dyspnea, and hemoptysis. Multiple bronchial biopsies combined with detailed clinical information suggested an amyloidosis disease. Red congo staining was positive in bronchial samples, and a further workup found positive red congo staining in subcutaneous fatty tissue biopsy samples. Tracheostomy was performed due to severe dyspnea related to laryngeal stenosis. A multidisciplinary consultation was held, and chemotherapy with melphalan and dexamethasone were prescribed due to the systemic effects of the disease. After 2 cycles of chemotherapy, the patient showed improvement in dyspnea and cough. Due to the inexperience of both the clinicians and pathologists, this case was diagnosed quite late. In the future, if this diagnosis is considered in the differential diagnosis, an earlier diagnosis and better treatment outcome can be reached.

【 授权许可】

Unknown