Molybdenum Diphosphide Nanorods with Laser‐Potentiated Peroxidase Catalytic/Mild‐Photothermal Therapy of Oral Cancer

Advanced Science

Hongyu Yang¹  Min Qian¹  Yuehong Shen¹  Guanghong Luo²  Massimiliano Galluzzi³  Ziqiang Cheng³  Zhibin Li³  Xue‐Feng Yu³ 

[1] Department of Oral and Maxillofacial Surgery Guangdong Provincial High‐level Clinical Key Specialty Guangdong Province Engineering Research Center of Oral Disease Diagnosis and Treatment Peking University Shenzhen Hospital Guangdong 518036 P. R. China;Department of Radiation Oncology The Second Clinical Medical College Jinan University (Shenzhen People's Hospital) Shenzhen Guangdong 518020 P. R. China;Materials and Interfaces Center Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen Guangdong 518055 P. R. China;

关键词: chemodynamic therapy;    mild‐photothermal therapy;    molybdenum diphosphide nanorods;    oral cancer;    peroxidase‐like catalytic;   

DOI  :  10.1002/advs.202101527

来源: DOAJ

【 摘 要 】

Abstract Chemodynamic therapy (CDT) is an emerging treatment that usually employs chemical agents to decompose hydrogen peroxide (H2O2) into hydroxyl radical (•OH) via Fenton or Fenton‐like reactions, inducing cell apoptosis or necrosis by damaging biomacromolecules such as, lipids, proteins, and DNA. Generally, CDT shows high tumor‐specificity and minimal‐invasiveness in patients, thus it has attracted extensive research interests. However, the catalytic reaction efficiency of CDT is largely limited by the relatively high pH at the tumor sites. Herein, a 808 nm laser‐potentiated peroxidase catalytic/mild‐photothermal therapy of molybdenum diphosphide nanorods (MoP2 NRs) is developed to improve CDT performance, and simultaneously achieve effective tumor eradication and anti‐infection. In this system, MoP2 NRs exhibit a favorable cytocompatibility due to their inherent excellent elemental biocompatibility. Upon irradiation with an 808 nm laser, MoP2 NRs act as photosensitizers to efficiently capture the photo‐excited band electrons and valance band holes, exhibiting enhanced peroxidase‐like catalytic activity to sustainedly decompose tumor endogenous H2O2 to •OH, which subsequently destroy the cellular biomacromolecules both in tumor cells and bacteria. As demonstrated both in vitro and in vivo, this system exhibits a superior therapeutic efficiency with inappreciable toxicity. Hence, the work may provide a promising therapeutic technique for further clinical applications.

【 授权许可】

Unknown