The Bcl-2 Family in Host-Virus Interactions

Viruses

Marc Kvansakul¹  Sofia Caria¹  Mark G. Hinds² 

[1] Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia;Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia;

关键词: Bcl-2;    apoptosis;    autophagy;    structural biology;    poxvirus;    herpesvirus;    asfarvirus;    iridovirus;    adenovirus;    host-pathogen interactions;   

DOI  :  10.3390/v9100290

来源: DOAJ

【 摘 要 】

Members of the B cell lymphoma-2 (Bcl-2) family are pivotal arbiters of mitochondrially mediated apoptosis, a process of fundamental importance during tissue development, homeostasis, and disease. At the structural and mechanistic level, the mammalian members of the Bcl-2 family are increasingly well understood, with their interplay ultimately deciding the fate of a cell. Dysregulation of Bcl-2-mediated apoptosis underlies a plethora of diseases, and numerous viruses have acquired homologs of Bcl-2 to subvert host cell apoptosis and autophagy to prevent premature death of an infected cell. Here we review the structural biology, interactions, and mechanisms of action of virus-encoded Bcl-2 proteins, and how they impact on host-virus interactions to ultimately enable successful establishment and propagation of viral infections.

【 授权许可】

Unknown