Reduced Cross-Frequency Coupling and Daytime Sleepiness in Obstructive Sleep Apnea Patients

Biology

Abdul Rauf Anwar¹  Nabin Koirala²  Sergiu Groppa³  Hao Ding³  Muthuraman Muthuraman³  Haralampos Gouveris⁴  Christoph Matthias⁴  Tilman Huppertz⁴  Katharina Ludwig⁴ 

[1] Department of Biomedical Engineering, University of Engineering and Technology (New Campus), Lahore 54890, Pakistan;Haskins Laboratories, Yale University, New Haven, CT 06511, USA;Movement Disorders and Neurostimulation, Biomedical Statistics and Multimodal Signal Processing Unit, Department of Neurology, University Medical Center of Johannes Gutenberg University Mainz, 55131 Mainz, Germany;Sleep Medicine Center, Department of Otolaryngology, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, Germany;

关键词: obstructive sleep apnea;    EEG;    cross-frequency coupling;    polysomnography;   

DOI  :  10.3390/biology11050700

来源: DOAJ

【 摘 要 】

Obstructive sleep apnea (OSA) is associated with sleep-stage- and respiratory-event-specific sensorimotor cortico-muscular disconnection. The modulation of phase–amplitude cross-frequency coupling (PACFC) may influence information processing throughout the brain. We investigated whether sleep-stage-specific PACFC is impaired at the sensorimotor areas in OSA patients. C3 and C4 electrode EEG polysomnography recordings of 170 participants were evaluated. Different frequency band combinations were used to compute CFC modulation index (MI) to assess if MI differs between OSA and non-significant OSA patients in distinct sleep stages. We tested if the CFC-MI could predict daytime sleepiness in OSA. Theta–gamma CFC-MI at cortical sensorimotor areas was significantly reduced during all sleep stages; the delta–alpha CFC-MI was significantly reduced during REM and N1 while increasing during N2 in patients with respiratory disturbance index (RDI) > 15/h compared to those with RDI ≤ 15/h. A sleep stage classification using MI values was achieved in both patient groups. Theta–gamma MI during N2 and N3 could predict RDI and Epworth Sleepiness Scale, while delta–alpha MI during REM predicted RDI. This increase in disconnection at the cortical sensorimotor areas with increasing respiratory distress during sleep supports a cortical motor dysfunction in OSA patients. The MI provides an objective marker to quantify subjective sleepiness and respiratory distress in OSA.

【 授权许可】

Unknown