Epstein-Barr Virus Mediated Signaling in Nasopharyngeal Carcinoma Carcinogenesis

Cancers

Tavan Janvilisri¹  Nurulfitri Wisetyaningsih²  Hisashi Iizasa³  Hironori Yoshiyama³  Pongphol Prattapong⁴  Chawalit Ngernsombat⁴  Timmy Richardo⁵ 

[1] Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand;Department of Biomedicine, Indonesia International Institute for Life Science (i3L), Jakarta 13210, Indonesia;Department of Microbiology, Shimane University, Izumo 693-8501, Japan;Graduate Program in Molecular Medicine, Faculty of Science, Mahidol University, Bangkok 10400, Thailand;Institute of Virology, Hannover Medical School, 30625 Hannover, Germany;

关键词: nasopharyngeal carcinoma;    EBV;    oncogenesis;    infection;    signaling pathway;   

DOI  :  10.3390/cancers12092441

来源: DOAJ

【 摘 要 】

Nasopharyngeal carcinoma (NPC) is one of the most common tumors occurring in China and Southeast Asia. Etiology of NPC seems to be complex and involves many determinants, one of which is Epstein-Barr virus (EBV) infection. Although evidence demonstrates that EBV infection plays a key role in NPC carcinogenesis, the exact relationship between EBV and dysregulation of signaling pathways in NPC needs to be clarified. This review focuses on the interplay between EBV and NPC cells and the corresponding signaling pathways, which are modulated by EBV oncoproteins and non-coding RNAs. These altered signaling pathways could be critical for the initiation and progression of NPC.

【 授权许可】

Unknown