Clinical and radiographic diagnostic study of strontium ranelate andmetal-substituted hydroxyapatite bone graft materials in diabetesmellitus with chronic periodontitis

Journal of Advanced Periodontology and Implant Dentistry

Bassant Mowafey¹  Atef Alasfar²  Omar Khashaba³  Enas Ahmed Elgendy⁴ 

[1] Lecturer of Oral Diagnosis and Oral Radiology, Faculty of Oral and Dental Medicine, Mansuora University, Egypt;M.S.C, Faculty of Oral and Dental Medicine, Mansuora University, Egypt;Professor of Oral Medicine, Periodontology, Oral Diagnosis, and Oral radiology Department, Faculty of Oral and Dental Medicine, Mansuora University, Egypt;Professor of Oral Medicine, Periodontology, and Oral Diagnosis Department, Faculty of Oral and Dental Medicine, Kafr El-Sheikh University, Egypt;

关键词: chronic periodontitis;    cone beam computed tomography;    diabetes mellitus;    metal-substituted hydroxyapatite;    periodontal flap;    strontium ranelate;   

DOI  :  10.34172/japid.2020.015

来源: DOAJ

【 摘 要 】

Background. The present study aimed to assess the clinical and radiographic effect of strontium ranelate and metal-substituted hydroxyapatite as bone graft materials on treating chronic periodontitis among diabetes mellitus patients. Methods. A randomized split-mouth study was conducted on 20 sites in 10 controlled type II diabetic patients suffering from chronic periodontitis. After phase I therapy, the sites were randomly allocated by a computer-generated table into two groups. Group 1: A mucoperiosteal flap was elevated in 10 sites, followed by the placement of strontium ranelate mixed with Gengigel. Group 2: A mucoperiosteal flap was elevated in 10 opposite sites, followed by the placement of metal-substituted hydroxyapatite mixed with Gengigel. Clinical parameters were assessed at baseline and 3- and 6-month intervals. Cone-beam computed tomography (CBCT) was used at baseline and after six months to assess bone gain. Results. The two treatment modalities resulted in a statistically significant reduction in clinical parameters at the 3- and 6-month intervals compared to the mean baseline value. Intergroup comparison showed a significant reduction in probing pocket depth and clinical attachment loss in group 1 compared to group 2. Comparison of the two sides by CBCT showed a significant increase in the alveolar bone height in the SR group than the metal-substituted hydroxyapatite group.Conclusion. Clinical and radiographic results showed a significant improvement in the two groups and provided evidence that strontium ranelate is promising in treating periodontal diseases.

【 授权许可】

Unknown