CRL Ubiquitin Ligases and DNA Damage Response

Frontiers in Oncology

Ju-Mei eLi¹  Jianping eJin¹ 

[1] The University of Texas Health Science Center at Houston;

关键词: Cyclin D1;    DNA Damage;    Protein degradation;    Cdc25A;    Cdt1;    Claspin;   

DOI  :  10.3389/fonc.2012.00029

来源: DOAJ

【 摘 要 】

Cullin/RING ubiquitin ligases (CRL) comprise the largest subfamily of ubiquitin ligases and are involved in various biological processes. One of the main functions of CRLs is to regulate DNA damage response, a fundamental signaling cascade to maintain genome integrity. In this review, we will discuss the regulation of CRL ubiquitin ligases and their roles in control of DNA damage response.

【 授权许可】

Unknown