Circulating biomarkers to monitor cancer progression and treatment

Computational and Structural Biotechnology Journal

关键词: cell-free DNA;    cell-free RNA;    cell-free microRNA;    cell-free circulating nucleic acids;    circulating tumor DNA;    circulating mutant DNA;   

DOI  :  10.1016/j.csbj.2016.05.004

来源: DOAJ

【 摘 要 】

Tumor heterogeneity is a major challenge and the root cause of resistance to treatment. Still, the standard diagnostic approach relies on the analysis of a single tumor sample from a local or metastatic site that is obtained at a given time point. Due to intratumoral heterogeneity and selection of subpopulations in diverse lesions this will provide only a limited characterization of the makeup of the disease. On the other hand, recent developments of nucleic acid sequence analysis allows to use minimally invasive serial blood samples to assess the mutational status and altered gene expression patterns for real time monitoring in individual patients. Here, we focus on cell-free circulating tumor-specific mutant DNA and RNA (including mRNA and non-coding RNA), as well as current limitations and challenges associated with circulating nucleic acids biomarkers.

【 授权许可】

Unknown