Role of long non-coding RNA in the pathogenesis of diabetic retinopathy

Guoji Yanke Zazhi

Xiu-Juan Yue¹  Ping Liu¹  Sheng Su¹ 

[1] Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China;

关键词: long non-coding RNA;    diabetic retinopathy;    gene regulation;    gene regulation;   

DOI  :  10.3980/j.issn.1672-5123.2017.10.12

来源: DOAJ

【 摘 要 】

Long non-coding RNA(LncRNA)is a class of transcript(>200 nucleotides)that do not encode proteins. It plays an important role in epigenetic regulation and gene expression at transcriptional or post transcriptional level. The abnormal expression of LncRNA may lead to various pathological processes. Diabetic retinopathy(DR)is a multifactorial disease. Recent studies have shown that many specific expressions of LncRNAs are closely related to the genesis of DR. In this review, we summarized the recent advances in the function of LncRNA, the regulatory mechanisms of LncRNA involved in the development of DR, and the related therapies.

【 授权许可】

Unknown