Tissue biomimicry using cross-linked electrospun nonwoven fibre composites

Current Directions in Biomedical Engineering

Schmitz Klaus-Peter¹  Illner Sabine²  Kohse Stefanie³  Arbeiter Daniela³  Grabow Niels³  Khaimov Valeria³  Senz Volkmar³  Teske Michael³  Oschatz Stefan³ 

[1] Institute for Biomedical Engineering, University Medical Center Rostock and Institute for Implant Technology and Biomaterials e.V.,Rostock, Germany;Institute for Biomedical Engineering, University Medical Center Rostock, Friedrich- Barnewitz-Str. 4, D-18119Rostock, Germany;Institute for Biomedical Engineering, University Medical Center Rostock,Rostock, Germany;

关键词: dual co-electrospinning;    nonwoven;    nanofibre;    microfibre;    composite;    posttreatment;    cardiovascular;    scaffold;   

DOI  :  10.1515/cdbme-2019-0031

来源: DOAJ

【 摘 要 】

Mimicking the structural properties of natural tissue was aimed to be achieved by combining complementary mechanical properties of materials showing high tensile strength with those of high elasticity. By using two polymers with different properties, the advantages of both can be combined to access innovative materials for biomedical applications. Dual co-electrospinning was established to generate biocompatible nonwoven fibre composites with fused properties from polyamide (PA6) and polyurethane based silicone elastomers (PU-co-Si), respectively. By electrospinning both compounds simultaneously, significant advantages, such as combining different fibre thicknesses and mechanical properties, are accessible. Furthermore, the effect on the fibres via an optional post-processing step in the shape of different thermal treatments was investigated. Initial results concerning surface morphology, biocompatibility and tensile properties of the obtained electrospun nonwovens are very auspicious. Thus, the suitability of two complementary polymer classes for tissue biomimicry through a synthetic approach was shown, offering the opportunity of novel implant materials for permanent replacement of biological tissue.

【 授权许可】

Unknown