The Influence of Thyroid Pathology on Osteoporosis and Fracture Risk: A Review

Diagnostics

Ondine Lucaciu¹  Daniel Oltean-Dan²  Andrei Maxim²  Dragos Apostu²  Horea Benea²  Alexandru-Dorin Mureșan³  Cristina Moisescu-Pop⁴ 

[1] Department of Oral Health, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca 400012, Romania;Department of Orthopedics and Traumatology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca 400132, Romania;Department of Sport and Physical Education Science, University of Babes-Bolyai, Cluj-Napoca 400376, Romania;Nuclear Medicine Department, “Prof. Dr. Ioan Chiricuța” Institute of Oncology, Cluj-Napoca 400015, Romania;

关键词: thyroid;    bone mineral density;    osteoporosis;    fracture;    hypothyroidism;    subclinical hypothyroidism;    subclinical hyperthyroidism;   

DOI  :  10.3390/diagnostics10030149

来源: DOAJ

【 摘 要 】

Thyroid hormones are important factors that regulate metabolism and cell differentiation throughout the human body. A complication of thyroid pathology is represented by an alteration of the bone metabolism which can lead to osteoporosis and fragility fractures, known to have a high mortality rate. Although there is a consensus on the negative impact of hyperthyroidism on bone metabolism, when referring to hypothyroidism, subclinical hypothyroidism, or subclinical hyperthyroidism, there is no general agreement. The aim of our review was to update clinicians and researchers about the current data regarding the bone health in hypothyroidism, subclinical hypothyroidism, and subclinical hyperthyroidism patients. Thyroid disorders have an important impact on bone metabolism and fracture risk, such that hyperthyroidism, hypothyroidism, and subclinical hyperthyroidism are associated with a decreased bone mineral density (BMD) and increased risk of fracture. Subclinical hypothyroidism, on the other hand, is not associated with osteoporosis or fragility fractures, and subclinical hyperthyroidism treatment with radioiodine could improve bone health.

【 授权许可】

Unknown