Omega-6 and Omega-3 Fatty Acid-Derived Oxylipins from the Lipoxygenase Pathway in Maternal and Umbilical Cord Plasma at Delivery and Their Relationship with Infant Growth

International Journal of Molecular Sciences

Maheswari Mukherjee¹  Elizabeth Lyden²  Sathish Kumar Natarajan³  Ana G. Yuil-Valdes⁴  Tara M. Nordgren⁵  Arzu Ulu⁵  Corrine K. Hanson⁶  Matthew Van Ormer⁷  Melissa Thoene⁷  Maranda Thompson⁷  Rebecca Slotkowski⁷  Ann Anderson Berry⁷ 

[1] Cytotechnology Education, College of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE 68198, USA;Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA;Department of Nutrition & Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA;Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA;Division of Biomedical Sciences, University of California Riverside, Riverside, CA 92521, USA;Medical Nutrition Education, College of Allied Health Profession, University of Nebraska Medical Center, Omaha, NE 68198, USA;Pediatrics Department, University of Nebraska Medical Center, Omaha, NE 68198, USA;

关键词: omega-3 fatty acids;    omega-6 fatty acids;    metabolites;    oxylipins;    plasma;    delivery;   

DOI  :  10.3390/ijms23020708

来源: DOAJ

【 摘 要 】

Omega-3 and omega-6 fatty acids are important for neonatal development and health. One mechanism by which omega-3 and omega-6 fatty acids exert their effects is through their metabolism into oxylipins and specialized pro-resolving mediators. However, the influence of oxylipins on fetal growth is not well understood. Therefore, the objective of this study was to identify oxylipins present in maternal and umbilical cord plasma and investigate their relationship with infant growth. Liquid chromatography–tandem mass spectrometry was used to quantify oxylipin levels in plasma collected at the time of delivery. Spearman’s correlations highlighted significant correlations between metabolite levels and infant growth. They were then adjusted for maternal obesity (normal body mass index (BMI: ≤30 kg/m²) vs. obese BMI (>30 kg/m²) and smoking status (never vs. current/former smoker) using linear regression modeling. A p-value < 0.05 was considered statistically significant. Our study demonstrated a diverse panel of oxylipins from the lipoxygenase pathway present at the time of delivery. In addition, both omega-3 and omega-6 oxylipins demonstrated potential influences on the birth length and weight percentiles. The oxylipins present during pregnancy may influence fetal growth and development, suggesting potential metabolites to be used as biomarkers for infant outcomes.

【 授权许可】

Unknown