Metabolic Syndrome Increases the Risk of Kidney Stone Disease: A Cross-Sectional and Longitudinal Cohort Study

Journal of Personalized Medicine

Jia-In Lee¹  Hung-Lung Ke²  Shu-Pin Huang²  Yung-Chin Lee³  Jhen-Hao Jhan³  Jung-Tsung Shen³  Hsun-Shuan Wang³  Yao-Hsuan Tsao³  Jiun-Hung Geng³  Che-Wei Chang³ 

[1] Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan;Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan;Department of Urology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 812, Taiwan;

关键词: epidemiologic study;    longitudinal study;    kidney stone;    metabolic syndrome;    risk factors;    diabetes mellitus;   

DOI  :  10.3390/jpm11111154

来源: DOAJ

【 摘 要 】

We aimed to examine the association between metabolic syndrome and the risk of kidney stone development in a large-scale community-based cohort. A total of 121,579 participants enrolled in the Taiwan Biobank were analyzed. They were divided into two groups on the basis of presence of metabolic syndrome. The presence of kidney stone disease was defined by self-reported history of kidney stones. The mean age of participants was 50 years old, and self-reported kidney stones were observed in 3446 (10%) and 4292 (5%) participants with metabolic syndrome and without metabolic syndrome, respectively. Higher prevalence of kidney stone disease was found in participants with metabolic syndrome compared to those without metabolic syndrome (odds ratio (OR), 1.32; 95% confidence interval (95% CI), 1.25 to 1.39). In addition, the risk of incident kidney stone development was analyzed in a longitudinal cohort of 25,263 participants without kidney stones at baseline during a mean follow-up of 47 months. Multivariable Cox regression analysis revealed that the risk for incident kidney stone disease was higher in participants with metabolic syndrome than those without metabolic syndrome (hazard ratio, 1.24; 95% CI, 1.04 to 1.49). Our study suggests that metabolic syndrome does increase the risk of kidney stones.

【 授权许可】

Unknown