Increased mortality in patients with secondary diagnosis of atrial fibrillation: Report from Chinese AF registry

Annals of Noninvasive Electrocardiology

Yan‐Min Yang¹  Xing‐Hui Shao¹  Li‐Sheng Liu¹  Li‐Tian Yu¹  Jun Zhu¹ 

[1] Emergency and Intensive Care Center Fuwai Hospital Chinese Academy Of Medical Sciences Beijing China;

关键词: atrial fibrillation;    diagnosis;    emergency medicine;    heart failure;    mortality;   

DOI  :  10.1111/anec.12774

来源: DOAJ

【 摘 要 】

Abstract Background The relationship between mortality and the primary diagnosis in AF patients is poorly recognized. The purpose of the study is to compare the differences on mortality in patients with a primary or secondary diagnosis of AF and to identify risk factors amenable to treatment. Methods This was a prospective cohort study using data from the Chinese AF registry. For admitted patients, a follow‐up was completed to obtain the outcomes during 1 year. Results A total of 2015 patients with confirmed AF were included. AF was the primary diagnosis in 40.9% (n = 825) of them. 78.9% (n = 939) of the secondary AF diagnosis patients and 55.5% (n = 458) of the primary AF diagnosis patients were sustained AF. Compared with primary AF diagnosis group, the secondary AF diagnosis group was older with more comorbidities. At 1 year, the unadjusted mortality was much higher in the secondary AF diagnosis groups compared with the primary AF diagnosis groups. In Cox regression analysis with adjustment for confounding factors, patients with secondary AF diagnosis were associated with an increased mortality (relative risk 1.723; 95% CI: 1.283 to 2.315, p < .001). On multivariate analysis, age ≥ 75, LVSD, COPD, and diabetes were independent predictors of mortality in patients with primary AF diagnosis, while for the secondary AF diagnosis group, the risk factors were age ≥ 75, heart failure, and previous history of stroke. Conclusions Patients presenting to ED with secondary diagnosis of AF were suffering from higher mortality risks compared with primary AF diagnosis patients. Physicians should distinguish these two groups in clinical practice.

【 授权许可】

Unknown