Pivotal regulators of tissue homeostasis and cancer: macrophages

Experimental Hematology & Oncology

Xiaobo Zhang¹  Yulei Chen¹ 

[1] College of Life Sciences, Zhejiang University;

关键词: Macrophage;    Phenotype;    Polarization;    Homeostasis;    Cancer;   

DOI  :  10.1186/s40164-017-0083-4

来源: DOAJ

【 摘 要 】

Abstract Macrophages are an essential component of innate immunity and play a vital role in inflammation and host defense. Based on immunological responses, the macrophages are classified into “activated” macrophage (M1 macrophages) participating in the responses of type I helper T (Th1) cells to pathogens and “alternatively activated” macrophages (M2 macrophages) in response to interleukin (IL)-4 and IL-13. In this review, we discuss the origin, classification and function of macrophages. We also discuss the mechanisms underlying polarization of different macrophage subtypes, including transcriptional, epigenetic and post-transcriptional regulation.

【 授权许可】

Unknown