Targeting cytoskeletal phosphorylation in cancer

Exploration of Targeted Anti-tumor Therapy

Clara Llorente-González¹  Miguel Vicente-Manzanares¹  Marta González-Rodríguez¹ 

[1] Molecular Mechanisms Program, Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-University of Salamanca, 37007 Salamanca, Spain;

关键词: cytoskeleton;    phosphorylation;    cancer;    actin;    tubulin;    vimentin;    myosin;   

DOI  :  10.37349/etat.2021.00047

来源: DOAJ

【 摘 要 】

Phosphorylation of cytoskeletal proteins regulates the dynamics of polymerization, stability, and disassembly of the different types of cytoskeletal polymers. These control the ability of cells to migrate and divide. Mutations and alterations of the expression levels of multiple protein kinases are hallmarks of most forms of cancer. Thus, altered phosphorylation of cytoskeletal proteins is observed in most cancer cells. These alterations potentially control the ability of cancer cells to divide, invade and form distal metastasis. This review highlights the emergent role of phosphorylation in the control of the function of the different cytoskeletal polymers in cancer cells. It also addresses the potential effect of targeted inhibitors in the normalization of cytoskeletal function.

【 授权许可】

Unknown