Cholesterol Transport Dysfunction and Its Involvement in Atherogenesis

International Journal of Molecular Sciences

Vasily N. Sukhorukov¹  Anastasia V. Poznyak²  Andrey V. Omelchenko²  Alexander N. Orekhov²  Vladislav Kalmykov³  Dmitry A. Kashirskikh³ 

[1] AP Avtsyn Research Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, Russia;Institute for Atherosclerosis Research, Osennyaya Street 4-1-207, 121609 Moscow, Russia;Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315 Moscow, Russia;

关键词: atherosclerosis;    cholesterol;    cholesterol transport;    LDL;   

DOI  :  10.3390/ijms23031332

来源: DOAJ

【 摘 要 】

Atherosclerosis is the cause of the development of serious cardiovascular disorders, leading to disability and death. Numerous processes are involved in the pathogenesis of atherosclerosis, including inflammation, endothelial dysfunction, oxidative stress, and lipid metabolism disorders. Reverse transport of cholesterol is a mechanism presumably underlying the atheroprotective effect of high-density lipoprotein. In this review, we examined disorders of cholesterol metabolism and their possible effect on atherogenesis. We paid special attention to the reverse transport of cholesterol. Transformed cholesterol metabolism results in dyslipidemia and early atherosclerosis. Reverse cholesterol transport is an endogenous mechanism by which cells export cholesterol and maintain homeostasis. It is known that one of the main factors leading to the formation of atherosclerotic plaques on the walls of blood vessels are multiple modifications of low-density lipoprotein, and the formation of foam cells following them.

【 授权许可】

Unknown