Serum Metabolic Profiling of Late-Pregnant Women With Antenatal Depressive Symptoms

Frontiers in Psychiatry

Tian Tian¹  Xunyi Guo²  Qiang Mao³  Xueli Zhang⁴  Jing Chen⁵  Tao Zou⁵ 

[1] Department of Neurology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China;Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China;Department of Pharmacology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;Department of Psychiatry, Linyi Mental Health Center, Linyi, China;Department of Psychiatry, The Affiliated Hospital of Guizhou Medical University, Guiyang, China;Shanghai Key Laboratory of Forensic Medicine (Academy of Forensic Science), Shanghai, China;

关键词: antenatal depression;    metabolomics;    edinburgh postnatal depression scale;    biomarker;    amino acid metabolism;    glycerophospholipid metabolism;   

DOI  :  10.3389/fpsyt.2021.679451

来源: DOAJ

【 摘 要 】

Background: Antenatal depression (AD) is a major public health issue worldwide and lacks objective laboratory-based tests to support its diagnosis. Recently, small metabolic molecules have been found to play a vital role in interpreting the pathogenesis of AD. Thus, non-target metabolomics was conducted in serum.Methods: Liquid chromatography—tandem mass spectrometry—based metabolomics platforms were used to conduct serum metabolic profiling of AD and non-antenatal depression (NAD). Orthogonal partial least squares discriminant analysis, the non-parametric Mann–Whitney U test, and Benjamini–Hochberg correction were used to identify the differential metabolites between AD and NAD groups; Spearman's correlation between the key differential metabolites and Edinburgh Postnatal Depression Scale (EPDS) and the stepwise logistic regression analysis was used to identify potential biomarkers.Results: In total, 79 significant differential metabolites between AD and NAD were identified. These metabolites mainly influence amino acid metabolism and glycerophospholipid metabolism. Then, PC (16:0/16:0) and betaine were significantly positively correlated with EPDS. The simplified biomarker panel consisting of these three metabolites [betaine, PC (16:0/16:0) and succinic acid] has excellent diagnostic performance (95% confidence interval = 0.911–1.000, specificity = 95%, sensitivity = 85%) in discriminating AD and NAD.Conclusion: The results suggested that betaine, PC (16:0/16:0), and succinic acid were potential biomarker panels, which significantly correlated with depression; and it could make for developing an objective method in future to diagnose AD.

【 授权许可】

Unknown