Current Evidence and Possible Future Applications of Creatine Supplementation for Older Adults

Nutrients

Ben Kirk¹  Gustavo Duque¹  ScottC. Forbes²  DarrenG. Candow³ 

[1] Department of Medicine-Western Health, the University of Melbourne, VIC, 3021, Australia;Faculty of Education, Department of Physical Education Studies, Brandon University, Brandon MB R7A6A9, Canada;Faculty of Kinesiology and Health Studies, University of Regina, Regina SK S4SOA2, Canada;

关键词: sarcopenia;    osteoporosis;    osteosarcopenia;    frailty;    cachexia;   

DOI  :  10.3390/nu13030745

来源: DOAJ

【 摘 要 】

Sarcopenia, defined as age-related reduction in muscle mass, strength, and physical performance, is associated with other age-related health conditions such as osteoporosis, osteosarcopenia, sarcopenic obesity, physical frailty, and cachexia. From a healthy aging perspective, lifestyle interventions that may help overcome characteristics and associated comorbidities of sarcopenia are clinically important. One possible intervention is creatine supplementation (CR). Accumulating research over the past few decades shows that CR, primarily when combined with resistance training (RT), has favourable effects on aging muscle, bone and fat mass, muscle and bone strength, and tasks of physical performance in healthy older adults. However, research is very limited regarding the efficacy of CR in older adults with sarcopenia or osteoporosis and no research exists in older adults with osteosarcopenia, sarcopenic obesity, physical frailty, or cachexia. Therefore, the purpose of this narrative review is (1) to evaluate and summarize current research involving CR, with and without RT, on properties of muscle and bone in older adults and (2) to provide a rationale and justification for future research involving CR in older adults with osteosarcopenia, sarcopenic obesity, physical frailty, or cachexia.

【 授权许可】

Unknown