Investigation of Incidents and Trends of Antimicrobial Resistance in Foodborne Pathogens in Eight Countries from Historical Sample Data

International Journal of Environmental Research and Public Health

Zuyi Huang¹  Matthew Fu²  Annie Wang²  Kevin Chen²  Katherine Yang²  Aaron Wang²  Qian Jia³ 

[1] Exercise Sciences, Immaculata University, Immaculata, PA 19345, USA;Department of Chemical Engineering, Villanova University, Villanova, PA 19085, USA;;Department of Health, Nutrition &

关键词: foodborne pathogens;    antimicrobial resistance;    principal component analysis;    hierarchical clustering;   

DOI  :  10.3390/ijerph17020472

来源: DOAJ

【 摘 要 】

Antimicrobial resistance (AMR) causes millions of illnesses every year, threatening the success of lifesaving antibiotic therapy and, thus, public health. To examine the rise and spread of antimicrobial resistance around the world, our study performs a multivariate statistical analysis of antimicrobial resistance gene data from eight different countries: the US, the UK, China, Brazil, Mexico, Canada, Australia, and South Africa. Multi-dimensional data points were projected onto a two-dimensional plane using principal component analysis and organized into a dendrogram utilizing hierarchical clustering to identify significant AMR genes and pathogens. Outlier genes/pathogens were typically involved in high occurrences of antimicrobial resistance, and they were able to indicate the trend of antimicrobial resistance in the future. Statistical analysis of the data identified: (1) tet(A), aph(3″)-Ib, aph(6)-Id, blaEC, blaTEM-1, qacEdelta1, sul1, sul2, and aadA1 as the nine most common AMR genes among the studied countries; (2) Salmonella enterica and E. coli and Shigella as the most common AMR foodborne pathogens; and (3) chicken as the most prevalent meat carrier of antimicrobial resistance. Our study shows that the overall number of reported antimicrobial resistance cases in foodborne pathogens is generally rising. One potential contributing factor for this is the increasing antimicrobial usage in the growing livestock industry.

【 授权许可】

Unknown