Recent advance in the discovery of tyrosinase inhibitors from natural sources via separation methods

Journal of Enzyme Inhibition and Medicinal Chemistry

Pei-ying Kang¹  Xiao-wei Zhang²  De-qiang Li³  Xin-jie Cheng³  Guang-li Bian³  Yong-li Liu⁴  Kai Yan⁴  Yan-xia Gao⁴ 

[1] Department of Clinical Laboratory, the Second Hospital of Hebei Medical University;Department of Neurological Surgery, the Second Hospital of Hebei Medical University;Department of Pharmacy, the Second Hospital of Hebei Medical University;Institute for Drug Control of Hebei Province;

关键词: tyrosinase inhibitors;    natural products;    rapid screening;    separation methods;   

DOI  :  10.1080/14756366.2021.1983559

来源: DOAJ

【 摘 要 】

Tyrosinase (TYR) inhibitors are in great demand in the food, cosmetic and medical industrials due to their important roles. Therefore, the discovery of high-quality TYR inhibitors is always pursued. Natural products as one of the most important sources of bioactive compounds discovery have been increasingly used for TYR inhibitors screening. However, due to their complex compositions, it is still a great challenge to rapid screening and identification of biologically active components from them. In recent years, with the help of separation technologies and the affinity and intrinsic activity of target enzymes, two advanced approaches including affinity screening and inhibition profiling showed great promises for a successful screening of bioactive compounds from natural sources. This review summarises the recent progress of separation-based methods for TYR inhibitors screening, with an emphasis on the principle, application, advantage, and drawback of each method along with perspectives in the future development of these screening techniques and screened hit compounds.

【 授权许可】

Unknown