Preparation and Applications of Organo-Silica Hybrid Mesoporous Silica Nanoparticles for the Co-Delivery of Drugs and Nucleic Acids

Nanomaterials

Iris Pontón¹  Marta Gómez Gómez¹  Andrea Martí del Rio¹  David Sánchez-García¹ 

[1] Grup d’Enginyeria de Materials (GEMAT), Institut Químic de Sarrià (IQS), Universitat Ramon Llull (URL), Via Augusta, 390, 08017 Barcelona, Spain;

关键词: mesoporous silica;    nanoparticles;    drug delivery;    co-delivery;    combination therapies;    RNA;   

DOI  :  10.3390/nano10122466

来源: DOAJ

【 摘 要 】

Combination therapies rely on the administration of more than one drug, with independent mechanisms of action, aiming to enhance the efficiency of the treatment. For an optimal performance, the implementation of such therapies requires the delivery of the correct combination of drugs to a specific cellular target. In this context, the use of nanoparticles (NP) as platforms for the co-delivery of multiple drugs is considered a highly promising strategy. In particular, mesoporous silica nanoparticles (MSN) have emerged as versatile building blocks to devise complex drug delivery systems (DDS). This review describes the design, synthesis, and application of MSNs to the delivery of multiple drugs including nucleic acids for combination therapies.

【 授权许可】

Unknown