Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties

International Journal of Molecular Sciences

Jiakun Xu¹  Yaqi Ren²  Chunlan Wang³  Shuaiyu Wang³ 

[1] Laboratory for Marine Drugs and Byproducts of Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266071, China;College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;Key Laboratory of Sustainable Development of Polar Fisheries, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences;

关键词: cafestol;    kahweol;    serum lipid;    anti-inflammation;    anti-tumor;    anti-diabetes;   

DOI  :  10.3390/ijms20174238

来源: DOAJ

【 摘 要 】

Cafestol and kahweol are natural diterpenes extracted from coffee beans. In addition to the effect of raising serum lipid, in vitro and in vivo experimental results have revealed that the two diterpenes demonstrate multiple potential pharmacological actions such as anti-inflammation, hepatoprotective, anti-cancer, anti-diabetic, and anti-osteoclastogenesis activities. The most relevant mechanisms involved are down-regulating inflammation mediators, increasing glutathione (GSH), inducing apoptosis of tumor cells and anti-angiogenesis. Cafestol and kahweol show similar biological activities but not exactly the same, which might due to the presence of one conjugated double bond on the furan ring of the latter. This review aims to summarize the pharmacological properties and the underlying mechanisms of cafestol-type diterpenoids, which show their potential as functional food and multi-target alternative medicine.

【 授权许可】

Unknown