β-thalassemia minor, carbohydrate malabsorption and histamine intolerance

Journal of Community Hospital Internal Medicine Perspectives

Michael Schenk¹  Wolfgang J. Schnedl²  Sandra J. Holasek²  Harald Mangge²  Sonja Lackner² 

[1] Das Kinderwunsch Institut Schenk GmbH;Medical University of Graz;

关键词: β-thalassemia minor;    lactose intolerance;    fructose malabsorption;    histamine intolerance;    nonspecific abdominal complaints;    diet;   

DOI  :  10.1080/20009666.2017.1369378

来源: DOAJ

【 摘 要 】

Background: β-thalassemia minor is characterized by reduced β-haemoglobin chain synthesis and sometimes mild anaemia, although carriers of β-thalassemia minorare usually clinically asymptomatic.Nonspecific abdominal complaints may be caused by gastrointestinal carbohydrate malabsorption (lactose and fructose) and/or malabsorption of biogenic amines (histamine), or proteins (gluten). Objectives: We report on two patients with β-thalassemia minor suffering nonspecific abdominal symptoms due to a carbohydrate and histamine malabsorption. Design/methods: The diagnosis of β-thalassemia minorwas done with peripheral blood smear and cellulose acetate electrophoresis. Carbohydrate malabsorption was diagnosed with hydrogen breath tests and, histamine intolerance (HIT) with a serum diamine oxidase value <10 U/ml and more than two gastrointestinal symptoms described for HIT. Conclusion: The symptoms of gastrointestinal malabsorption in these two patients with β-thalassemia minor were treated successfully with an individually-tailored diet free of symptom causing carbohydrates and histamine.

【 授权许可】

Unknown