Functional Fine-Tuning of Metabolic Pathways by the Endocannabinoid System—Implications for Health and Disease

International Journal of Molecular Sciences

EnricI. Canela¹  Estefanía Moreno¹  Milena Cavic² 

[1] Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, and Institute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain;Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia;

关键词: endocannabinoid system;    cancer;    cannabinoid receptor;    homeostasis;    metabolism regulation;   

DOI  :  10.3390/ijms22073661

来源: DOAJ

【 摘 要 】

The endocannabinoid system (ECS) employs a huge network of molecules (receptors, ligands, and enzymatic machinery molecules) whose interactions with other cellular networks have still not been fully elucidated. Endogenous cannabinoids are molecules with the primary function of control of multiple metabolic pathways. Maintenance of tissue and cellular homeostasis by functional fine-tuning of essential metabolic pathways is one of the key characteristics of the ECS. It is implicated in a variety of physiological and pathological states and an attractive pharmacological target yet to reach its full potential. This review will focus on the involvement of ECS in glucose and lipid metabolism, food intake regulation, immune homeostasis, respiratory health, inflammation, cancer and other physiological and pathological states will be substantiated using freely available data from open-access databases, experimental data and literature review. Future directions should envision capturing its diversity and exploiting pharmacological options beyond the classical ECS suspects (exogenous cannabinoids and cannabinoid receptor monomers) as signaling through cannabinoid receptor heteromers offers new possibilities for different biochemical outcomes in the cell.

【 授权许可】

Unknown