Human adrenocarcinoma (H295R) cells as potential predictors of bisphenols ability to interfere with steroid hormone production: a mini review

Scientific Papers Animal Science and Biotechnologies

关键词: bisphenols;    endocrine disruptors;    h295r;    steroidogenesis;   

DOI  :  

来源: DOAJ

【 摘 要 】

The focus on the refinement, reduction and replacement of animal use in toxicity testing requires the development of cell-based systems that mimic the effects of xenobiotics including bisphenols in human tissues. The human H295R adreno-carcinoma cell line provides a good in vitro system for the analysis of the human adrenal steroidogenic pathway at the level of hormone production and gene expression, because it expresses genes that encode for all the key enzymes for steroidogenesis. In this review we provide an introduction to H295R cell line and its use for research of toxicological effects of bisphenols, which represents an important contaminant.

【 授权许可】

Unknown