Interleukin-33: Its Emerging Role in Allergic Diseases

Molecules

Xing-Ning Lai¹  Li-Xia Xiong¹  Gui-Lin Zou¹  Hou-Wen Chen¹  Wen Ding¹  Wei Zhang² 

[1] Department of Pathophysiology, Medical College, Nanchang University, 461 Bayi Road, Nanchang 330006, China;Gannan Medical University, Rongjiang New Area, Ganzhou 341000, China;

关键词: interleukin-33;    allergic diseases;    target therapy;    asthma;    Th2-type immunity;   

DOI  :  10.3390/molecules23071665

来源: DOAJ

【 摘 要 】

Allergic diseases, which include asthma, allergic rhinitis (AR), chronic rhinosinusitis (CRS), atopic dermatitis (AD), food allergy (FA), allergic keratoconjunctivitis, seriously affect the quality of life of people all over the world. Recently, interleukin-33 (IL-33) has been found to play an important role in these refractory disorders, mainly by inducing T helper (Th) 2 immune responses. This article reviews the mobilization and biological function of IL-33 in allergic disorders, providing novel insights for addressing these hypersensitive conditions.

【 授权许可】

Unknown