Environmental Sources of Prion Transmission in Mule Deer

Emerging Infectious Diseases

关键词: chronic wasting disease (CWD);    cervid;    epidemiology;    mule deer;    Odocoileus hemionus;    prion;   

DOI  :  10.3201/eid1006.040010

来源: DOAJ

【 摘 要 】

Whether transmission of the chronic wasting disease (CWD) prion among cervids requires direct interaction with infected animals has been unclear. We report that CWD can be transmitted to susceptible animals indirectly, from environments contaminated by excreta or decomposed carcasses. Under experimental conditions, mule deer (Odocoileus hemionus) became infected in two of three paddocks containing naturally infected deer, in two of three paddocks where infected deer carcasses had decomposed in situ ≈1.8 years earlier, and in one of three paddocks where infected deer had last resided 2.2 years earlier. Indirect transmission and environmental persistence of infectious prions will complicate efforts to control CWD and perhaps other animal prion diseases.

【 授权许可】

Unknown