Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity

Molecules

Po-Hsun Chen¹  Chih-Chao Chiang²  Tsong-Long Hwang³  TranDinh Thang⁴  Hsin-Yi Hung⁵  Sio-Hong Lam⁵  Ping-Chung Kuo⁵  Tian-Shung Wu⁵ 

[1] Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan;Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 338, Taiwan;Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan;School of Chemistry, Biology and Environment, Vinh University, Vinh City 44000, Vietnam;School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan;

关键词: Menispermaceae;    lignan;    pyrrole alkaloid;    superoxide anion generation;    elastase release;   

DOI  :  10.3390/molecules23102541

来源: DOAJ

【 摘 要 】

Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

【 授权许可】

Unknown