Liver Enzymes Correlate With Metabolic Syndrome, Inflammation, and Endothelial Dysfunction in Prepubertal Children With Obesity

Frontiers in Pediatrics

Ramón Cañete¹  Luis Jiménez-Reina²  Rosario Martos³  María Dolores Cañete⁴  Rosario Valle-Martos⁵  Miguel Valle⁶ 

[1] Faculty of Medicine, Maimonides Biomedical Research Institute of Córdoba, Biomedical Research Networking Center for Physiopathology of Obesity and Nutrition, University of Cordoba, Córdoba, Spain;Faculty of Medicine, Maimonides Biomedical Research Institute of Córdoba, University of Cordoba, Córdoba, Spain;Health Center of Pozoblanco, Maimonides Biomedical Research Institute of Córdoba, Córdoba, Spain;Maimonides Biomedical Research Institute of Córdoba, Cordoba, Spain;Maimonides Biomedical Research Institute of Córdoba, University of Cordoba, Córdoba, Spain;Valle de los Pedroches Hospital, Maimonides Biomedical Research Institute of Córdoba, Córdoba, Spain;

关键词: liver enzymes;    prepuberal age;    obesity;    inflammation;    metabolic syndrome;    endothel dysfunction;   

DOI  :  10.3389/fped.2021.629346

来源: DOAJ

【 摘 要 】

Background: Metabolic syndrome (MetS) can start in children with obesity at very young ages. Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic component of metabolic syndrome. If left untreated, the clinical course of NAFLD can be progressive and can become chronic if not detected at an early stage.Objective: We aimed to quantify the differences in liver enzymes between prepubertal children with obesity and children with normal weight to determine any associations between them and parameters related to MetS, adipokines, or markers of endothelial dysfunction and inflammation.Methods: This cross-sectional study included 54 prepuberal children with obesity (aged 6–9 years) and 54 children with normal weight, matched by age and sex. Liver enzymes, C-reactive protein (CRP), interleukin-6, soluble intercellular adhesion molecule-1 (sICAM-1), adipokines, and parameters related to metabolic syndrome (MetS) were all measured.Results: Alanine aminotransferase (ALT) levels, serum butyryl cholinesterase (BChE), leptin, CRP, sICAM-1, triglycerides, blood pressure, and homeostasis model assessment for insulin resistance were significantly higher in children with obesity, while Apolipoprotein A-1, HDL-cholesterol, and adiponectin were significantly lower. In the children with obesity group, ALT and BChE levels correlated with anthropometric measurements, insulin resistance, and lipid parameters, leptin, interleukin-6, CRP, and sICAM-1 while BChE levels negatively correlated with adiponectin.Conclusions: Compared to children with normal weight, prepubertal children with obesity had elevated values for liver enzymes, leptin, markers of insulin resistance, inflammation, and endothelial dysfunction, and variables associated with MetS. There was also a correlation between these disorders and liver enzyme levels.

【 授权许可】

Unknown