Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity

eLife

Alexander A Chubykin¹  Jeffrey P Gavornik²  Lena A Khibnik³  Robert W Komorowski⁴  Mark F Bear⁴  Eitan S Kaplan⁴  Sam F Cooke⁴  Aurore Thomazeau⁴ 

[1] Department of Biological Sciences, Purdue University, West Lafayette, United States;Department of Biology, Boston University, Boston, United States;Department of Neurology, Sanford Health, Fargo, United States;Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States;

关键词: ocular dominance plasticity;    recognition memory;    ketamine;    schizophrenia;    stimulus-selective response potentiation;    orientation-selective habituation;   

DOI  :  10.7554/eLife.11450

来源: DOAJ

【 摘 要 】

The roles played by cortical inhibitory neurons in experience-dependent plasticity are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult mice: ocular dominance (OD) plasticity resulting from monocular deprivation and stimulus-selective response potentiation (SRP) resulting from enriched visual experience. These two forms of plasticity are triggered by different events but lead to a similar increase in visual cortical response. Both also require the NMDA class of glutamate receptor (NMDAR). However, we find that PV+ inhibitory neurons in V1 play a critical role in the expression of SRP and its behavioral correlate of familiarity recognition, but not in the expression of OD plasticity. Furthermore, NMDARs expressed within PV+ cells, reversibly inhibited by the psychotomimetic drug ketamine, play a critical role in SRP, but not in the induction or expression of adult OD plasticity.

【 授权许可】

Unknown