Growing vertical aligned mesoporous silica thin film on nanoporous substrate for enhanced degradation, drug delivery and bioactivity

Bioactive Materials

Jing Liu¹  Yumei Zhang¹  Yide He¹  Lasse Hyldgaard Klausen²  Fanghao Chen²  Wen Song³  Ning Yan⁴  Mingdong Dong⁴  Zhe Li⁴ 

[1] National Clinical Research Center for Oral Diseases &Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China;Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, 8000, Denmark;;State Key Laboratory of Military Stomatology &

关键词: Mesoporous silica film;    Vertical aligned mesochannels;    Titania nanotubes array;    Drug delivery;    Osteoblasts;   

DOI  :  

来源: DOAJ

【 摘 要 】

Mesoporous silica thin film has been widely used in various fields, particularly the medical implant coating for drug delivery. However, some drawbacks remain with the films produced by traditional method (evaporation-induced self-assembly, EISA), such as the poor permeability caused by their horizontal aligned mesochannels. In this study, the vertical aligned mesoporous silica thin film (VMSTF) is uniformly grown alongside the walls of titania nanotubes array via a biphase stratification growth method, resulting in a hierarchical two-layered nanotubular structure. Due to the exposure of opened mesopores, VMSTF exhibits more appealing performances, including rapid degradation, efficient small-molecular drug (dexamethasone) loading and release, enhanced early adhesion and osteogenic differentiation of MC3T3-E1 cells. This is the first time successfully depositing VMSTF on nanoporous substrate and our findings suggest that the VMSTF may be a promising candidate for bone implant surface coating to obtain bioactive performances.

【 授权许可】

Unknown