Molecular Mechanisms of Changes in Homeostasis of the Dermal Extracellular Matrix: Both Involutional and Mediated by Ultraviolet Radiation

International Journal of Molecular Sciences

Dmitry Kudlay¹  Alla Zorina²  Vadim Zorin²  Pavel Kopnin³ 

[1] Department of Pharmacology, Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia;Human Stem Cells Institute, 119333 Moscow, Russia;N.N. Blokhin National Medical Research Oncology Center, Ministry of Health of Russia, 115478 Moscow, Russia;

关键词: skin;    extracellular matrix;    collagen;    aging;    fibroblasts;   

DOI  :  10.3390/ijms23126655

来源: DOAJ

【 摘 要 】

Skin aging is a multi-factorial process that affects nearly every aspect of skin biology and function. With age, an impairment of structures, quality characteristics, and functions of the dermal extracellular matrix (ECM) occurs in the skin, which leads to disrupted functioning of dermal fibroblasts (DFs), the main cells supporting morphofunctional organization of the skin. The DF functioning directly depends on the state of the surrounding collagen matrix (CM). The intact collagen matrix ensures proper adhesion and mechanical tension in DFs, which allows these cells to maintain collagen homeostasis while ECM correctly regulates cellular processes. When the integrity of CM is destroyed, mechanotransduction is disrupted, which is accompanied by impairment of DF functioning and destruction of collagen homeostasis, thereby contributing to the progression of aging processes in skin tissues. This article considers in detail the processes of skin aging and associated changes in the skin layers, as well as the mechanisms of these processes at the molecular level.

【 授权许可】

Unknown