Common Genetic Variations Involved in the Inter-Individual Variability of Circulating Cholesterol Concentrations in Response to Diets: A Narrative Review of Recent Evidence

Nutrients

Charles Desmarchelier¹  MohammadM. H. Abdullah²  JamesD. House³  PeterJ. H. Jones⁴  Itzel Vazquez-Vidal⁵  DavidJ. Baer⁶ 

[1] Aix Marseille University, INRAE, INSERM, C2VN, 13005 Marseille, France;Department of Food Science and Nutrition, Kuwait University, Kuwait City 10002, Kuwait;Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada;Nutritional Fundamentals for Health, Vaudreuil-Dorion, QC J7V 5V5, Canada;Richardson Centre for Functional Foods & Nutraceuticals, University of Manitoba, Winnipeg, MB R3T 6C5, Canada;United States Department of Agriculture, Agricultural Research Service, Beltsville, MD, 20705, USA;

关键词: lipids;    gene-diet interaction;    personalized nutrition;    single nucleotide polymorphism;    genetic variant;    cardiovascular diseases;   

DOI  :  10.3390/nu13020695

来源: DOAJ

【 摘 要 】

The number of nutrigenetic studies dedicated to the identification of single nucleotide polymorphisms (SNPs) modulating blood lipid profiles in response to dietary interventions has increased considerably over the last decade. However, the robustness of the evidence-based science supporting the area remains to be evaluated. The objective of this review was to present recent findings concerning the effects of interactions between SNPs in genes involved in cholesterol metabolism and transport, and dietary intakes or interventions on circulating cholesterol concentrations, which are causally involved in cardiovascular diseases and established biomarkers of cardiovascular health. We identified recent studies (2014–2020) that reported significant SNP–diet interactions in 14 cholesterol-related genes (NPC1L1, ABCA1, ABCG5, ABCG8, APOA1, APOA2, APOA5, APOB, APOE, CETP, CYP7A1, DHCR7, LPL, and LIPC), and which replicated associations observed in previous studies. Some studies have also shown that combinations of SNPs could explain a higher proportion of variability in response to dietary interventions. Although some findings still need replication, including in larger and more diverse study populations, there is good evidence that some SNPs are consistently associated with differing circulating cholesterol concentrations in response to dietary interventions. These results could help clinicians provide patients with more personalized dietary recommendations, in order to lower their risk for cardiovascular disease.

【 授权许可】

Unknown