General Psychopathology, Cognition, and the Cerebral Cortex in 10-Year-Old Children: Insights From the Adolescent Brain Cognitive Development Study

Frontiers in Human Neuroscience

Giovanni A. Salum¹  Tomáš Paus²  Nadine Parker³  Yash Patel³  Zdenka Pausova⁴ 

[1] Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;Departments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hopitalier Universitaire Sainte-Justine, University of Montreal, Montreal, QC, Canada;Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada;The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada;

关键词: MRI;    brain development;    cerebral cortex;    growth;    cohort;   

DOI  :  10.3389/fnhum.2021.781554

来源: DOAJ

【 摘 要 】

General psychopathology and cognition are likely to have a bidirectional influence on each other. Yet, the relationship between brain structure, psychopathology, and cognition remains unclear. This brief report investigates the association between structural properties of the cerebral cortex [surface area, cortical thickness, intracortical myelination indexed by the T1w/T2w ratio, and neurite density assessed by restriction spectrum imaging (RSI)] with general psychopathology and cognition in a sample of children from the Adolescent Brain Cognitive Development (ABCD) study. Higher levels of psychopathology and lower levels of cognitive ability were associated with a smaller cortical surface area. Inter-regionally—across the cerebral cortex—the strength of association between an area and psychopathology is strongly correlated with the strength of association between an area and cognition. Taken together, structural deviations particularly observed in the cortical surface area influence both psychopathology and cognition.

【 授权许可】

Unknown