The effects of magnesium-zinc-calcium-vitamin D co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes

BMC Pregnancy and Childbirth

Maryam Chamani¹  Fereshteh Bahmani²  Masoumeh Eslahi²  Zatollah Asemi²  Naghmeh Mirhosseini³  Mehri Jamilian⁴  Maryam Shokrpour⁴ 

[1] Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences;Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences;School of Public Health, University of Saskatchewan;Traditional and Complementary Medicine Research Center, Arak University of Medical Sciences;

关键词: Supplementation;    Multinutrients;    Gestational diabetes;    Pregnancy;    Inflammation;   

DOI  :  10.1186/s12884-019-2258-y

来源: DOAJ

【 摘 要 】

Abstract Background Diabetes is the most common medical condition in pregnant women and its complications affect both mother and fetus. The beneficial effects of vitamin D on gestational diabetes have been shown, though data on the effects of co-administration of vitamin D with other nutrients on pregnancy outcomes in gestational diabetes (GDM) are scarce. This study was aimed to determine the effects of magnesium-zinc-calcium-vitamin D co-supplementation on parameters of inflammation and oxidative stress, and pregnancy outcomes among women with GDM. Methods This randomized, double-blinded, placebo-controlled trial was conducted on 60 women with GDM not taking oral hypoglycemic agents. Patients were randomly assigned to take magnesium-zinc-calcium-vitamin D supplements (n = 30) or placebo (n = 30) for 6 weeks. Fasting blood samples were collected from participants at baseline and after the 6-week intervention to measure related biomarkers. Results Magnesium-zinc-calcium-vitamin D co-supplementation resulted in a significant reduction in serum high-sensitivity C-reactive protein (− 1.2 ± 3.5 vs. + 0.8 ± 2.0 mg/L, P = 0.01) and plasma malondialdehyde concentrations (− 0.3 ± 0.3 vs. + 0.3 ± 1.1 μmol/L, P = 0.003), as well as a significant increase in total antioxidant capacity levels (+ 38.2 ± 76.5 vs. -16.3 ± 93.5 mmol/L, P = 0.01), compared to placebo. We found a decreasing trend in newborns’ weight (3089.8 ± 519.9 vs. 3346.3 ± 411.1 g, P = 0.05) and the rate of macrosomia (3.3% vs. 16.7%, P = 0.08) in the magnesium-zinc-calcium-vitamin D supplemented women. Conclusions Overall, the findings of this study have demonstrated that magnesium-zinc-calcium-vitamin D co-supplementation for 6 weeks to women with GDM may reduce biomarkers of inflammation and oxidative stress. This study was retrospectively registered on 25 April 2017 in the Iranian website (www.irct.ir) for clinical trials registration (http://www.irct.ir: IRCT201704225623N109).

【 授权许可】

Unknown