A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives

Journal of Advanced Research

A.K.M. Atique Ullah¹  Takeshi Saito²  Masaaki Kurasaki³  Subrata Banik³  Mahmuda Akter³  Md. Mostafizur Rahman³  Kaniz Fatima Binte Hossain³  Md. Tajuddin Sikder⁴  Toshiyuki Hosokawa⁵ 

[1] Chemistry Division, Atomic Energy Centre, Bangladesh Atomic Energy Commission, Dhaka 1000, Bangladesh;Faculty of Health Sciences, Hokkaido University, Sapporo 060-0817, Japan;Graduate School of Environmental Science, Hokkaido University, 060-0810 Sapporo, Japan;Group of Environmental Adaptation Science, Faculty of Environmental Earth Science, Hokkaido University, Kita 10, Nishi 5, Kita-ku, 060-0810 Sapporo, Japan;Research Division of Higher Education, Institute for the Advancement of Higher Education, Hokkaido University, Sapporo 060-0817, Japan;

关键词: Silver nanoparticles;    Cytotoxicity;    Physiochemical properties;    Mechanism;   

DOI  :  10.1016/j.jare.2017.10.008

来源: DOAJ

【 摘 要 】

With the development of nanotechnology, silver nanoparticles (Ag-NPs) have become one of the most in-demand nanoparticles owing to their exponential number of uses in various sectors. The increased use of Ag-NPs-enhanced products may result in an increased level of toxicity affecting both the environment and living organisms. Several studies have used different model cell lines to exhibit the cytotoxicity of Ag-NPs, and their underlying molecular mechanisms. This review aimed to elucidate different properties of Ag-NPs that are responsible for the induction of cellular toxicity along with the critical mechanism of action and subsequent defense mechanisms observed in vitro. Our results show that the properties of Ag-NPs largely vary based on the diversified synthesis processes. The physiochemical properties of Ag-NPs (e.g., size, shape, concentration, agglomeration, or aggregation interaction with a biological system) can cause impairment of mitochondrial function prior to their penetration and accumulation in the mitochondrial membrane. Thus, Ag-NPs exhibit properties that play a central role in their use as biocides along with their applicability in environmental cleaning. We herein report a current review of the synthesis, applicability, and toxicity of Ag-NPs in relation to their detailed characteristics.

【 授权许可】

Unknown