Supplemental progesterone during early pregnancy exerts divergent responses on embryonic characteristics in sows and gilts

Animal

C.A. Oliveira¹  G.M. Ravagnani¹  A.P. Poor¹  D.F. Leal¹  D.H. Nakasone¹  M.V. Mendonça¹  S.M.M.K. Martins¹  B.B.D. Muro¹  A.F.C. de Andrade¹  P. Viau¹  M.A. Torres¹  C.H.G. Martinez¹  M.S. Monteiro¹  R.F. Carnevale¹  G.W. Almond²  L.H. Pulz³  R.F. Strefezzi³ 

[1] Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo05508-270, Brazil;Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC27606, USA;Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Pirassununga13635-900, Brazil;

关键词: embryo development;    uterine histoarchitecture;    progestagen;    altrenogest;    swine;   

DOI  :  

来源: DOAJ

【 摘 要 】

Progesterone (P4) plays a key role in pregnancy establishment and maintenance; during early pregnancy, P4 stimulates the production and release of uterine secretions necessary for conceptus growth prior to implantation; therefore, exogenous P4 supplementation may improve embryo development. This study evaluated the effects of supplementation during early pregnancy with long-acting injectable progesterone or altrenogest on embryonic characteristics of sows and gilts. Thus, a total of 32 sows and 16 gilts were used. On day 6 of pregnancy sows and gilts were allocated to one of the following groups: non-supplemented; supplemented with 20 mg of altrenogest, orally, from days 6 to 12 of pregnancy; supplemented with 2.15 mg/kg of long-acting injectable progesterone on day 6 of pregnancy. Animals were killed on day 28 of pregnancy, and ovulation rate, embryo survival, embryo weight, crown-to-rump length, uterine glandular epithelium and endometrial vascularization were assessed. Treatments had no effect on pregnancy rate, embryo survival or endometrial vascular density (P > 0.05). Non-supplemented gilts presented larger and heavier embryos compared to gilts from supplemented groups (P < 0.05). Sows in the altrenogest group presented larger and heavier embryos compared to non-supplemented sows and sows supplemented with long-acting injectable progesterone. In conclusion, supplementation of sows and gilts with progestagen from day 6 of pregnancy can be used as a means to improve embryo survival without deleterious effects.

【 授权许可】

Unknown