Effects of Macrolide Treatment during the Hospitalization of Children with Childhood Wheezing Disease: A Systematic Review and Meta-Analysis

Journal of Clinical Medicine

Tzu-Lin Yeh¹  Hsin-Hui Lin²  Shu-Jung Liu³  Hua-His Hung⁴  Mu-Chieh Tsai⁴  Chien-Yu Lin⁴  Yu-Jyun Cheng⁴  Wei-Te Lei⁴  Jui-Ming Liu⁵ 

[1] Department of Family Medicine, Hsinchu MacKay Memorial Hospital, Hsinchu 30071, Taiwan;Department of Family Medicine, Taipei MacKay Memorial Hospital, Taipei 10449, Taiwan;Department of Medical Library, MacKay Memorial Hospital, Tamsui Branch, New Taipei City 25160, Taiwan;Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu 30071, Taiwan;Division of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 33004, Taiwan;

关键词: wheezing;    asthma;    bronchiolitis;    macrolide;    azithromycin;    childhood wheezing disease;   

DOI  :  10.3390/jcm7110432

来源: DOAJ

【 摘 要 】

Children are susceptible to a variety of respiratory infections. Wheezing is a common sign presented by children with respiratory infections. Asthma, bronchiolitis, and bronchitis are common causes of childhood wheezing disease (CWD) and are regarded as overlapping disease spectra. Macrolides are common antimicrobial agents with anti-inflammatory effects. We conducted a comprehensive literature search and a systematic review of studies that investigated the influences of macrolide treatment on CWD. The primary outcomes were the impact of macrolides on hospitalization courses of patients with CWD. Data pertaining to the study population, macrolide treatment, hospital courses, and recurrences were analyzed. Twenty-three studies with a combined study population of 2210 patients were included in the systematic review. Any kind of benefit from macrolide treatment was observed in approximately two-thirds of the studies (15/23). Eight studies were included in the meta-analysis to investigate the influence of macrolides on the length of stay (LOS), duration of oxygen demand (DOD), symptoms and signs of respiratory distress, and re-admission rates. Although the benefits of macrolide treatment were reported in several of the studies, no significant differences in LOS, DOD, symptoms and signs of respiratory distress, or re-admission rates were observed in patients undergoing macrolide treatment. In conclusion, any kind of benefit of macrolide treatment was observed in approximately two-thirds of the studies; however, no obvious benefits of macrolide treatment were observed in the hospitalization courses of children with CWD. The routine use of macrolides to improve the hospitalization course of children with CWD is not suggested.

【 授权许可】

Unknown