Why Should Growth Hormone (GH) Be Considered a Promising Therapeutic Agent for Arteriogenesis? Insights from the GHAS Trial

Cells

ClaraV. Alvarez¹  Diego Caicedo²  Pablo Devesa³  Jesús Devesa⁴ 

[1]. Neoplasia and Endocrine Differentiation Research Group. Center for Research in Molecular Medicine and Chronic Diseases (CIMUS). University of Santiago de Compostela, 15782. Santiago de Compostela, Spain

[2]Department of Angiology and Vascular Surgery, Complejo Hospitalario Universitario de Santiago de Compostela, 15706 Santiago de Compostela, Spain

[3]Research and Development, The Medical Center Foltra, 15886 Teo, Spain

[4]Scientific Direction, The Medical Center Foltra, 15886 Teo, Spain

关键词: GH and eNOS;    IGF-I;    oxidative stress and arterial inflammation;    vascular homeostasis;    neovascularization;    arteriogenesis;   

DOI  :  10.3390/cells9040807

来源: DOAJ

【 摘 要 】

Despite the important role that the growth hormone (GH)/IGF-I axis plays in vascular homeostasis, these kind of growth factors barely appear in articles addressing the neovascularization process. Currently, the vascular endothelium is considered as an authentic gland of internal secretion due to the wide variety of released factors and functions with local effects, including the paracrine/autocrine production of GH or IGF-I, for which the endothelium has specific receptors. In this comprehensive review, the evidence involving these proangiogenic hormones in arteriogenesis dealing with the arterial occlusion and making of them a potential therapy is described. All the elements that trigger the local and systemic production of GH/IGF-I, as well as their possible roles both in physiological and pathological conditions are analyzed. All of the evidence is combined with important data from the GHAS trial, in which GH or a placebo were administrated to patients suffering from critical limb ischemia with no option for revascularization. We postulate that GH, alone or in combination, should be considered as a promising therapeutic agent for helping in the approach of ischemic disease.

【 授权许可】

Unknown