Interaction of Gender and Hepatitis C in Risk of Chronic Renal Failure After Liver Transplantation

Annals of Hepatology

Eric M. Yoshida¹  Ip Stephen¹  Vladimir Marquez¹  Siegfried R. Erb¹  Nilufar Partovi²  Trana Hussaini²  Aliya Daulat² 

[1] Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada;Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada;

关键词: Liver transplant;    Kidney failure;    Calcineurin inhibitors;    Gender;    Prognosis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background. Chronic renal failure (CRF) is a significant cause of morbidity and mortality in post-liver transplantation (LT) recipients. The risk factors associated with the development of renal dysfunction are not clearly elucidated. Objectives. To examine the risk factors in the development of CRF in these patients.Material and methods. Retrospective case-cohort of liver transplant patients without baseline kidney dysfunction who developed chronic renal failure during their follow-up.Results. Of 370 patients, 254 met the inclusion criteria. 30% (76) of these patients had CRF of which 57% (43) were male. Age, estimated glomerular filtration rate (eGFR) at discharge, and HCV infection were found to be risk factors for CRF post-LT. The odds ratio of developing CRF was 1.4 (0.6-3.3) in males with HCV, 1.6 (0.7-3.9) in females without HCV and 4.4 (1.5-13.2) among females with HCV when compared to men without HCV.Conclusions. In this cohort of LT receipients of a major Canadian city, age, eGFR, and HCV infection were risk factors for CRF. Female gender and HCV increased this odds by a factor of more than 4.

【 授权许可】

Unknown