Exosomes: Potential Biomarkers and Functions in Head and Neck Squamous Cell Carcinoma

Frontiers in Molecular Biosciences

Hongjiang He¹  Jiayu Zhao¹  Ting Li¹  Mingze Yan¹  Juan Li²  Shan Yu²  Haitao Wang³ 

[1] Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, China;Department of Pathology, Second Affiliated Hospital of Harbin Medical University, Harbin, China;Thoracic Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States;

关键词: head and neck squamous cell carcinoma;    exosome;    biomarkers;    therapeutic target;    drug carrier;   

DOI  :  10.3389/fmolb.2022.881794

来源: DOAJ

【 摘 要 】

Head and neck squamous cell carcinoma (HNSCC), originating from the mucosal epithelial cells of the oral cavity, pharynx, and larynx, is a lethal malignancy of the head and neck. Patients with advanced and recurrent HNSCC have poor outcomes due to limited therapeutic options. Exosomes have active roles in the pathophysiology of tumors and are suggested as a potential therapeutic target of HNSCC. Exosomes in HNSCC have been intensively studied for disease activity, tumor staging, immunosuppression, and therapeutic monitoring. In this review, the biological mechanisms and the recent clinical application of exosomes are highlighted to reveal the potential of exosomes as biomarkers and therapeutic targets for HNSCC.

【 授权许可】

Unknown