Metabolic Effects of Resistant Starch Type 2: A Systematic Literature Review and Meta-Analysis of Randomized Controlled Trials

Nutrients

Deanna Manolas¹  NicoleJ. Kellow¹  Audrey Louise¹  Matthew Snelson²  Jessica Jong³  Smonda Kok³  Romi Stern³ 

[1] Food, Monash University, Level 1, 264 Ferntree Gully Road, Notting Hill, VIC 3168, Australia;Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia;;Department of Nutrition, Dietetics &

关键词: resistant starch;    dietary fiber;    obesity;    metabolic syndrome;    type 2 diabetes;    metabolic health;    systematic review;   

DOI  :  10.3390/nu11081833

来源: DOAJ

【 摘 要 】

Published evidence exploring the effects of dietary resistant starch (RS) on human cardiometabolic health is inconsistent. This review aimed to investigate the effect of dietary RS type 2 (RS2) supplementation on body weight, satiety ratings, fasting plasma glucose, glycated hemoglobin (HbA1c), insulin resistance and lipid levels in healthy individuals and those with overweight/obesity, the metabolic syndrome (MetS), prediabetes or type 2 diabetes mellitus (T2DM). Five electronic databases were searched for randomized controlled trials (RCTs) published in English between 1982 and 2018, with trials eligible for inclusion if they reported RCTs involving humans where at least one group consumed ≥ 8 g of RS2 per day and measured body weight, satiety, glucose and/or lipid metabolic outcomes. Twenty-two RCTs involving 670 participants were included. Meta-analyses indicated that RS2 supplementation significantly reduced serum triacylglycerol concentrations (mean difference (MD) = −0.10 mmol/L; 95% CI −0.19, −0.01, P = 0.03) in healthy individuals (n = 269) and reduced body weight (MD = −1.29 kg; 95% CI −2.40, −0.17, P = 0.02) in people with T2DM (n = 90). However, these outcomes were heavily influenced by positive results from a small number of individual studies which contradicted the conclusions of the majority of trials. RS2 had no effects on any other metabolic outcomes. All studies ranged from 1−12 weeks in duration and contained small sample sizes (10−60 participants), and most had an unclear risk of bias. Short-term RS2 supplementation in humans is of limited cardiometabolic benefit.

【 授权许可】

Unknown