Targeting of activated fibroblasts for imaging and therapy

EJNMMI Radiopharmacy and Chemistry

Frederik Giesel¹  Clemens Kratochwil¹  Annette Altmann¹  Thomas Lindner¹  Anastasia Loktev¹  Uwe Haberkorn¹ 

[1]Department of Nuclear Medicine, University Hospital Heidelberg

关键词: Cancer-associated fibroblast;    Tumor stroma;    Fibroblast activation protein;    Inhibitors;    Imaging;   

DOI  :  10.1186/s41181-019-0069-0

来源: DOAJ

【 摘 要 】

Abstract Tumors form a complex environment consisting of a variety of non-malignant cells. Especially cancer-associated fibroblasts have been shown to have an important role for different aspects of malignant tumors such as migration, metastasis, resistance to chemotherapy and immunosuppression. Therefore, a targeting of these cells may be useful for both imaging and therapy. In this respect, an interesting target is the fibroblast activation protein (FAP) which is expressed in activated fibroblasts, but not in quiescent fibroblasts, giving the opportunity to use this membrane-anchored enzyme as a target for radionuclide-based approaches for diagnosis and treatment of tumors and for the diagnosis of non-malignant disease associated with a remodelling of the extracellular matrix.

【 授权许可】

Unknown