Role of Gene Therapy in Pancreatic Cancer—A Review

Cancers

Masato Yamamoto¹  Mizuho Sato-Dahlman¹  Keith Wirth¹ 

[1] Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA;

关键词: pancreatic cancer;    pancreatic adenocarcinoma;    virotherapy;    oncolytic;    non-viral vector;    RNA interference;    siRNA;   

DOI  :  10.3390/cancers10040103

来源: DOAJ

【 摘 要 】

Mortality from pancreatic ductal adenocarcinoma (PDAC) has remained essentially unchanged for decades and its relative contribution to overall cancer death is projected to only increase in the coming years. Current treatment for PDAC includes aggressive chemotherapy and surgical resection in a limited number of patients, with median survival of optimal treatment rather dismal. Recent advances in gene therapies offer novel opportunities for treatment, even in those with locally advanced disease. In this review, we summarize emerging techniques to the design and administration of virotherapy, synthetic vectors, and gene-editing technology. Despite these promising advances, shortcomings continue to exist and here will also be highlighted those approaches to overcoming obstacles in current laboratory and clinical research.

【 授权许可】

Unknown